python 示例：

  from hashlib import md5
  import base64

  def get_signature(appkey, appsecret, ts, uid):
      h = md5()
      h.update(("appkey=" + appkey + "&appsecret=" + appsecret + "&ts=" + str(ts) + "&uid=" + uid).encode())
      r = base64.b64encode(h.digest())
      return r

  sign = get_signature('appkey', 'appsecret', 1583907259426, 'uid')
  print(sign)